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This drug is also known as sibutramine hydrochloride monohydrate, is a drug of choice in treating obesity because it suppresses appetite. It is manufactured by Abbott Laboratories under three brand names: Meridia, Reductil and Sibutrex. Currently it has been suspended in countries like UK and Europe. It is also under review by the European Medicines Agency and FDA due to its mechanism of action is related to amphetamines. It is categorized under the Schedule IV controlled substance in the USA due to its lacking dopaminergic effects. In the mid- 20th century, “overprescription” of anorectics that resulted in a number of addiction.
It is absorbed coming from the GI tract but it reduces its bioavailability because it undergoes first pass metabolism. The peak plasma level is reached after an hour and also it has a half-life of one hour. The active metabolites have a peak plasma concentrations of three to four hours. The other metabolites are excreted in the urine. This drug reduces the reuptake of serotonin, dopamine and norepinephrine thus increase level of this substances aids the serotonergic action that is thought to affect appetite. Even if this drug have the same action as to the other tricyclic antidepressants, this drug fails to demonstrate antidepressant properties. It was in November 1997 that FDA approved Meridia as a treatment of obesity. This drug is not recommended to patients with psychiatric conditions like bulimia nervosa, serious depressions and anorexia nervosa. It is not also recommended to patients having a history of drug abused and alcohol abuse, patients below 18 years old and also patients taking MAO inhibitor, other centrally active drugs and antidepressants. Patients having history of peripheral arterial disease and patients having uncontrolled hypertension, with existing damage on heart valves, congestive heart failurem coronary heart disease, with a history of myocardial infarction are not advised to take this drug. Lactating women and pregnant women are also discouraged to take this drug.